Runs right by my house... what would you like to know?
I know it can be done in just over a week if you don't have ADD. It goes by a lot of cool stuff so if you do have ADD you can take all the time in the world to run the length of the route.
Lots of opportunities for primitive camping, but double check which areas have designated primitive sites and which areas require permits. Things a little different on the east coast than out west on BLM land. There are plenty of place to camp outside of campgrounds, but it's a little trickier than the "park almost anywhere" approach out west.
The route itself is pretty tame. Mostly dirt/gravel forest service roads passible by anything 4wd. Some areas are better groomed than others and will be a few ounces of tar short of a paved road. Others are less maintained and prone to ruts and washouts necessitating 4wd for some sections.
As far as your truck, you'll be fine. Might be some areas that get a little tight with the Mountain Lural, so be prepared form some "West Virginia Pin Stripes." Beyond that you might hit the occasional low branch, but nothing I'd be too worried about. Might not hurt to pack a pole saw just in case.
Let me know when you're passing through and if I can provide any additional local knowledge (food, beverage, camping, entertainment, etc) let me know.